Antifouling Electrospun Nanofiber Mats Functionalized with Polymer Zwitterions
| Autor: | Katrina A. Rieger, Todd Emrick, Jessica D. Schiffman, Kerianne M. Dobosz, Chia Chih Chang, Kristopher W. Kolewe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Materials science 02 engineering and technology Polymer engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biofouling Contact angle chemistry.chemical_compound chemistry Coating Polymerization Nanofiber Zwitterion Polymer chemistry engineering General Materials Science Cellulose 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 8:27585-27593 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.6b09839 |
| Popis: | In this study, we exploit the excellent fouling resistance of polymer zwitterions and present electrospun nanofiber mats surface functionalized with poly(2-methacryloyloxyethyl phosphorylcholine) (polyMPC). This zwitterionic polymer coating maximizes the accessibility of the zwitterion to effectively limit biofouling on nanofiber membranes. Two facile, scalable methods yielded a coating on cellulose nanofibers: (i) a two-step sequential deposition featuring dopamine polymerization followed by the physioadsorption of polyMPC, and (ii) a one-step codeposition of polydopamine (PDA) with polyMPC. While the sequential and codeposited nanofiber mat assemblies have an equivalent average fiber diameter, hydrophilic contact angle, surface chemistry, and stability, the topography of nanofibers prepared by codeposition were smoother. Protein and microbial antifouling performance of the zwitterion modified nanofiber mats along with two controls, cellulose (unmodified) and PDA coated nanofiber mats were evaluated by dynamic protein fouling and prolonged bacterial exposure. Following 21 days of exposure to bovine serum albumin, the sequential nanofiber mats significantly resisted protein fouling, as indicated by their 95% flux recovery ratio in a water flux experiment, a 300% improvement over the cellulose nanofiber mats. When challenged with two model microbes Escherichia coli and Staphylococcus aureus for 24 h, both zwitterion modifications demonstrated superior fouling resistance by statistically reducing microbial attachment over the two controls. This study demonstrates that, by decorating the surfaces of chemically and mechanically robust cellulose nanofiber mats with polyMPC, we can generate high performance, free-standing nanofiber mats that hold potential in applications where antifouling materials are imperative, such as tissue engineering scaffolds and water purification technologies. |
| Databáze: | OpenAIRE |
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