Proteinuria in sickle cell trait and disease: an electrophoretic analysis
| Autor: | L. Comoe, J. Lonsdorfer, A. Lonsdorfer, A. E. Yapo |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system Clinical Biochemistry Cell Early detection Ultrafiltration Urine Disease Anemia Sickle Cell Biochemistry Gastroenterology Excretion Sex Factors Internal medicine medicine Humans Child Sickle cell trait Proteinuria business.industry Biochemistry (medical) Age Factors General Medicine medicine.disease Molecular Weight Endocrinology medicine.anatomical_structure Electrophoresis Polyacrylamide Gel Female medicine.symptom business |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 181(3) |
| ISSN: | 0009-8981 |
| Popis: | Using ultrafiltration and SDS-PAGE, abnormal urinary protein excretion was found in 25.4% of 189 persons with sickle cell disease and trait, but none of 72 controls. Based upon molecular weight of urinary proteins, underlying renal lesions were classified as glomerular, tubular, or both. Altered protein excretion appeared at an early age, was more abnormal in older subjects, and was related to the severity of sickle cell disease (SS greater than SC = S/beta Thal greater than AS). Since none of the subjects had yet developed clinically significant renal disease, SDS-PAGE may permit early detection of patients who require careful follow-up or aggressive therapy. |
| Databáze: | OpenAIRE |
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