Exploring the genetic correlations of antisocial behaviour and life history traits
| Autor: | Arne Popma, James J. Lee, Tinca J. C. Polderman, Danielle Posthuma, Jorim J. Tielbeek, Brian B. Boutwell, John R. B. Perry, J. C. Barnes |
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| Přispěvatelé: | Perry, John [0000-0001-6483-3771], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genome-wide association study antisocial behaviour Short Report Quantitative trait locus Biology Genetic correlation Life history theory 03 medical and health sciences Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine Negatively associated Allele 030217 neurology & neurosurgery Evolutionary theory Behavioural genetics linkage disequilibrium regression Demography |
| Zdroj: | BJPsych Open Tielbeek, J J, Barnes, J C, Popma, A, Polderman, T J C, Lee, J J, Perry, J R B, Posthuma, D & Boutwell, B B 2018, ' Exploring the genetic correlations of antisocial behaviour and life history traits ', BJPsych Open, vol. 4, no. 6, pp. 467-470 . https://doi.org/10.1192/bjo.2018.63 |
| ISSN: | 2056-4724 |
| Popis: | SummaryPrior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776–318 863) and antisocial behaviour (N = 31 968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg = 0.50, P = 0.0065) were positively correlated with alleles associated with antisocial behaviour, whereas alleles associated with more delayed reproductive onset (age at first birth, rg = −0.64, P = 0.0008) were negatively associated with alleles linked to antisocial behaviour. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviours may partly represent a faster life history approach, which may be significantly calibrated by genes.Declaration of interestNone. |
| Databáze: | OpenAIRE |
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