Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Autor:	Oro Uchenunu, Alexander V. Zhdanov, Phillipe Hutton, Predrag Jovanovic, Ye Wang, Dmitry E. Andreev, Laura Hulea, David J. Papadopoli, Daina Avizonis, Pavel V. Baranov, Michael N. Pollak, Dmitri B. Papkovsky, Ivan Topisirovic
Rok vydání:	2022
Předmět:	Electron Transport Complex IV Humans HCT116 Cells Proto-Oncogene Proteins c-akt General Biochemistry Genetics and Molecular Biology Mitochondria Molecular Chaperones
Zdroj:	FEBS Open Bio. 12:959-982
ISSN:	2211-5463
DOI:	10.1002/2211-5463.13398
Popis:	Mutations in genes encoding cytochrome c oxidase (mitochondrial complex IV) subunits and assembly factors [e.g., synthesis of cytochrome c oxidase 2 (SCO2)] are linked to severe metabolic syndromes. Notwithstanding that SCO2 is under transcriptional control of tumor suppressor p53, the role of mitochondrial complex IV dysfunction in cancer metabolism remains obscure. Herein, we demonstrate that the loss of SCO2 in HCT116 colorectal cancer cells leads to significant metabolic and signaling perturbations. Specifically, abrogation of SCO2 increased NAD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acefde85b9236aaa7dc50f34f4fb7f4 https://doi.org/10.1002/2211-5463.13398 Zobrazit plný text záznamu Plný text