Variability of magnetoencephalographic sensor sensitivity measures as a function of age, brain volume and cortical area
| Autor: | Timothy T. Brown, Andrei Irimia, Matthew Erhart |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Adolescent Models Neurological Audiology Sensitivity and Specificity Article Young Adult Physiology (medical) medicine Humans Sensitivity (control systems) Young adult Child Lead field Cerebral Cortex medicine.diagnostic_test Age Factors Infant Magnetoencephalography Sensory Systems Neurology Child Preschool Brain size Feasibility Studies Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 125(10) |
| ISSN: | 1872-8952 |
| Popis: | To assess the feasibility and appropriateness of magnetoencephalography (MEG) for both adult and pediatric studies, as well as for the developmental comparison of these factors across a wide range of ages.For 45 subjects with ages from 1 to 24years (infants, toddlers, school-age children and young adults), lead fields (LFs) of MEG sensors are computed using anatomically realistic boundary element models (BEMs) and individually-reconstructed cortical surfaces. Novel metrics are introduced to quantify MEG sensor focality.The variability of MEG focality is graphed as a function of brain volume and cortical area. Statistically significant differences in total cerebral volume, cortical area, MEG global sensitivity and LF focality are found between age groups.Because MEG focality and sensitivity differ substantially across the age groups studied, the cortical LF maps explored here can provide important insights for the examination and interpretation of MEG signals from early childhood to young adulthood.This is the first study to (1) investigate the relationship between MEG cortical LFs and brain volume as well as cortical area across development, and (2) compare LFs between subjects with different head sizes using detailed cortical reconstructions. |
| Databáze: | OpenAIRE |
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