Effects of maternal nutrient restriction during the periconceptional period on placental development in the mouse
Autor: | Laura C. Schulz, Kathryn M. Storey, Gerialisa Van Gronigen Case, Lauren E. Parmeley |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Embryology Placenta Maternal Health Prenatal Nutritional Physiological Phenomena Biochemistry Fetal Development Mice Human fertilization Pregnancy Medicine and Health Sciences DNA methylation Multidisciplinary Obstetrics and Gynecology Chromatin Trophoblasts Nucleic acids medicine.anatomical_structure Fetal circulation Gestation Medicine Epigenetics Female Anatomy DNA modification Chromatin modification Research Article Chromosome biology Cell biology Science Biology Real-Time Polymerase Chain Reaction Andrology Genetics medicine Animals Nutrition Caloric Restriction Fetus Biology and life sciences Reproductive System DNA Nutrients medicine.disease Placentation Diet Food Fertilization Women's Health Blastocysts Gene expression Developmental Biology |
Zdroj: | PLoS ONE, Vol 16, Iss 1, p e0244971 (2021) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Maternal undernutrition has detrimental effects on fetal development and adult health. Total caloric restriction during early pregnancy followed by adequate nutrition for the remainder of gestation, is particularly linked to cardiovascular and metabolic disease risks during adulthood. The placenta is responsible for transport of nutrients from the maternal to fetal circulation, and the efficiency with which it does so can be adjusted to the maternal nutrient supply. There is evidence that placental adaptations to nutrient restriction in early pregnancy may be retained even when adequate nutrition is restored later in pregnancy, leading to a potential mismatch between placental efficiency and maternal nutrient supplies. However, in the mouse, 50% caloric restriction from days 1.5–11.5 of gestation, while temporarily altering placental structure and gene expression, had no significant effect on day 18.5. The periconceptional period, during which oocyte maturation, fertilization, and preimplantation development occur may be especially critical in creating lasting impact on the placenta. Here, mice were subjected to 50% caloric restriction from 3 weeks prior to pregnancy through d11.5, and then placental structure, the expression of key nutrient transporters, and global DNA methylation levels were examined at gestation d18.5. Prior exposure to caloric restriction increased maternal blood space area, but decreased expression of the key System A amino acid transporter Slc38a4 at d18.5. Neither placental and fetal weights, nor placental DNA methylation levels were affected. Thus, total caloric restriction beginning in the periconceptional period does have a lasting impact on placental development in the mouse, but without changing placental efficiency. |
Databáze: | OpenAIRE |
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