Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review
| Autor: | Christophe Rochais, Alban Lepailleur, Sangeetha-Laura Thirumaran |
|---|---|
| Přispěvatelé: | Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences 010405 organic chemistry Chemistry Organic Chemistry Context (language use) General Medicine Disease Serotonergic 01 natural sciences 3. Good health 0104 chemical sciences 03 medical and health sciences Drug Discovery [CHIM]Chemical Sciences Identification (biology) Serotonin Pharmacophore Receptor Neuroscience 030304 developmental biology |
| Zdroj: | European Journal of Medicinal Chemistry European Journal of Medicinal Chemistry, Elsevier, 2019, 183, pp.111705-. ⟨10.1016/j.ejmech.2019.111705⟩ |
| ISSN: | 0223-5234 1768-3254 |
| DOI: | 10.1016/j.ejmech.2019.111705⟩ |
| Popis: | 5-HT7 receptors are the most recently discovered serotonergic receptors, for which numerous physiological implications in the central and the peripheral nervous systems as well as the endocrine system are described. A current public health challenge is to propose new and more efficient treatments against neuropsychiatric disorders such as epilepsy or Alzheimer's disease. In this context, 5-HT7 receptors represent an interesting target for the treatment and prevention of those pathologies, as an alternative or in association with other medicines. Thus, numerous chemical series of agonists and antagonists have been developed. Some of these molecules have shown a therapeutic potential in various in vivo studies. This review aims to present an overview of 5-HT7 receptors and of the medicinal chemistry programs that led to the identification of new, potent and selective 5-HT7 receptors ligands. Structure-activity relationships studies based on molecular docking and pharmacophoric approaches are also described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect