N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)
| Autor: | A. Robert MacLeod, Robert Deziel, Eric Therrien, Anne-Christine Goulet, Sylvia Styhler, Sukhdev Manku, Gabi Rahil, Hannah Nguyen, Andrea J. Petschner, Martin Allan, Natalie Nguyen, Jeffrey M. Besterman, Amal Wahhab, Marie-France Robert |
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| Rok vydání: | 2008 |
| Předmět: |
Protein-Arginine N-Methyltransferases
Trifluoromethyl CARM1 Molecular Structure Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Isoindoline Thiophenes Pyrazole Biochemistry Amides chemistry.chemical_compound chemistry Drug Discovery Pyridine Thiophene Molecular Medicine Combinatorial Chemistry Techniques Pyrazoles Benzofuran Thiazole Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 19(4) |
| ISSN: | 1464-3405 |
| Popis: | A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potency of these inhibitors was influenced by the nature of the heteroaryl fragment with the thiophene analogues being superior to thiazole, pyridine, isoindoline and benzofuran based inhibitors. |
| Databáze: | OpenAIRE |
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