Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats
| Autor: | Javier Bolaños, Pablo Muriel, Gustavo Torres, Jose M. Barral |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis medicine.medical_treatment Alpha interferon Calcium-Transporting ATPases Biology Liver Cirrhosis Experimental Fibrosis Internal medicine medicine Animals Rats Wistar Carbon Tetrachloride Interferon alfa Phospholipids Pharmacology Liver injury Cell Membrane Erythrocyte Membrane Interferon-alpha General Medicine medicine.disease Rats Red blood cell medicine.anatomical_structure Endocrinology Cytokine Cholesterol Liver Hepatocyte Sodium-Potassium-Exchanging ATPase medicine.drug |
| Zdroj: | Pharmacology. 48(1) |
| ISSN: | 0031-7012 |
| Popis: | Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of alpha-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCl4-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca(2+)-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p0.05). Administration of interferon (80,000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of alpha-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect. |
| Databáze: | OpenAIRE |
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