Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
| Autor: | Jerry Kok Yen Chan, Zhaoyuan Liu, Anis Larbi, Abhay P. S. Rathore, Hassen Kared, Jing Wen Hang, Rasha Msallam, Ashley L. St. John, Florent Ginhoux, Jozef Balla, Wilfried A. A. Saron, Benoit Malleret, Charles-Antoine Dutertre |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Allergy Placenta Receptors Fc Immunoglobulin E medicine.disease_cause Cell Degranulation Mice 03 medical and health sciences Fetus 0302 clinical medicine Neonatal Fc receptor Allergen Pregnancy Hypersensitivity medicine Animals Humans Mast Cells Maternal-Fetal Exchange Sensitization Multidisciplinary biology business.industry Histocompatibility Antigens Class I Degranulation Allergens medicine.disease Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Immunology biology.protein Female Ambrosia business 030215 immunology |
| Zdroj: | Science. 370:941-950 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Maternal IgE activates fetal mast cells Mast cells (MCs) are immune cells that participate in allergic reactions through their activation by immunoglobulin E (IgE) antibodies. MCs arise early during mammalian development, but it is unclear whether IgE-mediated activation occurs in fetal tissues and what the source of IgE stimulation is. Msallam et al. show that human and mouse fetal MCs can be sensitized by IgE of maternal origin, which crosses the placental barrier through the fetal neonatal Fc receptor (see the Perspective by Rothenberg). Prenatal maternal sensitization conferred transient allergen sensitivity after birth and resulted in the development of postnatal skin and airway inflammation in the offspring after their first exposure to allergen. Thus, both maternal IgE and fetal MCs may influence mother-to-child transmission of allergic disease during gestation. Science , this issue p. 941 ; see also p. 907 |
| Databáze: | OpenAIRE |
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