A novel flurophore-cyano-carboxylic-Ag microhybrid: Enhanced two photon absorption for two-photon photothermal therapy of HeLa cancer cells by targeting mitochondria
| Autor: | Hongping Zhou, Lin Kong, Mingzhu Zhang, Huihui Zhang, Chen-Qi Xin, Lin Li, Shu-Juan Zhu, Jiaxiang Yang, Li Yang, Yupeng Tian |
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| Rok vydání: | 2018 |
| Předmět: |
Acetonitriles
Silver Cell Survival Carbazoles Biomedical Engineering Biophysics Metal Nanoparticles Quantum yield 02 engineering and technology Acetates 010402 general chemistry Photochemistry 01 natural sciences Two-photon absorption Silver nanoparticle Electron transfer Piperidines Electrochemistry Humans Surface plasmon resonance Absorption (electromagnetic radiation) Fluorescent Dyes Photons Dose-Response Relationship Drug Chemistry General Medicine Phototherapy Surface Plasmon Resonance Photothermal therapy 021001 nanoscience & nanotechnology Fluorescence Mitochondria 0104 chemical sciences 0210 nano-technology HeLa Cells Biotechnology |
| Zdroj: | Biosensors and Bioelectronics. 108:14-19 |
| ISSN: | 0956-5663 |
| DOI: | 10.1016/j.bios.2018.02.028 |
| Popis: | In this study, a novel two-photon photothermal therapy (TP-PTT) agent based on an organic-metal microhybrid with surface Plasmon resonance (SPR) enhanced two-photon absorption (TPA) characteristic was designed and synthesized using a fluorescent cyano-carboxylic derivative 2-cyano-3-(9-ethyl-9H-carbazol-3-yl) -acrylic acid (abbreviated as CECZA) and silver nanoparticles through self-assembly process induced by the interfacial coordination interactions between the O/N atom of CECZA and Ag+ion at the surface of Ag nanoparticles. The coordination interactions caused electron transfer from the Ag nanoparticles to CECZA molecules at the excited state, resulting in a decreased fluorescence quantum yield. The interfacial coordination interactions also enhanced the nonlinear optical properties, including 13 times increase in the TPA cross-section (δ). The decreased fluorescence quantum yield and increased two photon absorption caused by the SPR effect led excellent two-photon photothermal conversion, which was beneficial for the TP-PTT effect on HeLa cancer cells. |
| Databáze: | OpenAIRE |
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