Evaluation of the diagnostic value of peripheral BDNF levels for Alzheimer’s disease and mild cognitive impairment: results of a meta-analysis
| Autor: | Huimin Zhou, Wenxuan Liu, Zanchao Liu, Dongsheng Cui, Bing Xie, Shunjiang Xu, Zhongli Shi, Weifang Yu, Lei Jiang, Rui Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Disease Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Neurotrophic factors Internal medicine medicine Humans Cognitive Dysfunction Cognitive impairment Brain-derived neurotrophic factor business.industry Brain-Derived Neurotrophic Factor General Neuroscience General Medicine Peripheral 030104 developmental biology Meta-analysis business Value (mathematics) Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Neuroscience. 130:218-230 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.1080/00207454.2019.1667794 |
| Popis: | Deregulation of brain-derived neurotrophic factor (BDNF) is a possible contributor to the pathology and symptoms of Alzheimer's disease (AD). Most studies support an association between the dysfunction of BDNF and the pathogenesis of AD. This study aimed to evaluate the diagnostic value of peripheral BDNF levels in patients with AD and mild cognitive impairment (MCI) using meta-analytic techniques. A systematic search of the MEDLINE, EMBASE, ISI Web of Science, and the Cochrane Central database was performed and 34 eligible articles were identified for inclusion in the meta-analysis. Random-effects meta-analysis showed that AD patients had significantly decreased levels of peripheral BDNF compared with healthy control (HC) subjects (Hedges' |
| Databáze: | OpenAIRE |
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