Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling
| Autor: | Elizabeth Moore, James Roberts, Beverly Barton Rogers, Carla Ransom, Jeanette D Cheng, Minhui Ma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Placental Finding Placenta Syncytiotrophoblasts Fibrin Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Syncytiotrophoblast Pregnancy medicine Humans Pregnancy Complications Infectious skin and connective tissue diseases Histiocyte 030219 obstetrics & reproductive medicine biology business.industry SARS-CoV-2 fungi Karyorrhexis Infant Newborn COVID-19 General Medicine medicine.disease Immunohistochemistry Trophoblasts body regions Histiocytosis medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health biology.protein Female business |
| Zdroj: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 24(6) |
| ISSN: | 1615-5742 |
| Popis: | Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition. |
| Databáze: | OpenAIRE |
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