Acceleration of enzyme-catalyzed reactions in organic solvents by crown ethers

Autor:	Jaap Broos, Inge M. Rouwenhorst, Willem Verboom, David N. Reinhoudt, Marie-Noelle Martin
Přispěvatelé:	Faculty of Science and Technology, Molecular Nanofabrication, X-ray Crystallography
Jazyk:	angličtina
Rok vydání:	1991
Předmět:	Enzyme catalyzed stomatognathic system Chemistry Crown (botany) Organic chemistry General Chemistry Transesterification Ethyl ester Catalysis
Zdroj:	Recueil des travaux chimiques des Pays-Bas, 110(5), 222-225. Royal Netherlands Chemical Society Recueil des Travaux Chimiques des Pays-Bas, 110, 222-225
ISSN:	0165-0513 1878-7096
Popis:	Crown ethers can strongly enhance the transesterification of N-acetyl-1-phenylalanine ethyl ester with 1-propanol catalyzed by α-chymotrypsin in various organic solvents. Of the different crown ethers tested, 18-C-6 gave the best results. It was found that a macrocyclic effect is responsible for the observed rate enhancement. It is proposed that the water- and cation-complexing ability of crown ethers plays a key role in the observed rate enhancement.
Databáze:	OpenAIRE
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