Effect of respiratory motion on cardiac defect contrast in myocardial perfusion SPECT: a physical phantom study
| Autor: | Matti J. Kortelainen, Mikko Hakulinen, Tuomas Koivumäki, Marko Vauhkonen |
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| Rok vydání: | 2018 |
| Předmět: |
Technetium Tc 99m Sestamibi
Phantom Movement Imaging phantom Cardiac apex 030218 nuclear medicine & medical imaging 03 medical and health sciences Myocardial perfusion imaging Cardiac phantom 0302 clinical medicine Image Processing Computer-Assisted Medicine Radiology Nuclear Medicine and imaging Respiratory system Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Phantoms Imaging Respiration Respiratory motion Heart General Medicine 030220 oncology & carcinogenesis SPECT Original Article business Lateral wall Nuclear medicine Artifacts Perfusion |
| Zdroj: | Annals of Nuclear Medicine |
| ISSN: | 1864-6433 |
| Popis: | Objective Correction for respiratory motion in myocardial perfusion imaging requires sorting of emission data into respiratory windows where the intra-window motion is assumed to be negligible. However, it is unclear how much intra-window motion is acceptable. The aim of this study was to determine an optimal value of intra-window residual motion. Methods A custom-designed cardiac phantom was created and imaged with a standard dual-detector SPECT/CT system using Tc-99m as the radionuclide. Projection images were generated from the list-mode data simulating respiratory motion blur of several magnitudes from 0 (stationary phantom) to 20 mm. Cardiac defect contrasts in six anatomically different locations, as well as myocardial perfusion of apex, anterior, inferior, septal and lateral walls, were measured at each motion magnitude. Stationary phantom data were compared to motion-blurred data. Two physicians viewed the images and evaluated differences in cardiac defect visibility and myocardial perfusion. Results Significant associations were observed between myocardial perfusion in the anterior and inferior walls and respiratory motion. Defect contrasts were found to decline as a function of motion, but the magnitude of the decline depended on the location and shape of the defect. Defects located near the cardiac apex lost contrast more rapidly than those located on the anterior, inferior, septal and lateral wall. The contrast decreased by less than 5% at every location when the motion magnitude was 2 mm or less. According to a visual evaluation, there were differences in myocardial perfusion if the magnitude of the motion was greater than 1 mm, and there were differences in the visibility of the cardiac defect if the magnitude of the motion was greater than 9 mm. Conclusions Intra-window respiratory motion should be limited to 2 mm to effectively correct for respiratory motion blur in myocardial perfusion SPECT. |
| Databáze: | OpenAIRE |
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