Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development

Autor:	Quinn A. Bonafiglia, Yu-Qing Zhou, Guangpei Hou, Rhidita Saha, Ying-Han R. Hsu, Jonah Burke-Kleinman, Michelle P. Bendeck
Rok vydání:	2022
Předmět:	Pulmonary and Respiratory Medicine Mice Epithelial-Mesenchymal Transition Discoidin Domain Receptor 1 Hypertension Pulmonary Clinical Biochemistry Infant Newborn Animals Humans Cell Biology Fibrosis Molecular Biology Bronchopulmonary Dysplasia
Zdroj:	American Journal of Respiratory Cell and Molecular Biology. 67:562-573
ISSN:	1535-4989 1044-1549
DOI:	10.1165/rcmb.2022-0124oc
Popis:	Pulmonary hypertension (PH) is a multifaceted condition characterized by elevated pulmonary arterial pressure, which can result in right ventricular dysfunction and failure. Disorders of lung development can present with secondary PH, which is a leading cause of mortality in infants with bronchopulmonary dysplasia (BPD). DDR1 (discoidin domain receptor 1) is a collagen-binding receptor that regulates tissue fibrosis and inflammation and controls cellular growth and migration. However, the roles of DDR1 in lung development or the pathogenesis of PH are unknown. Studying mice with a DDR1 deletion (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac525c364e24f0976ac730873dfd2dc https://doi.org/10.1165/rcmb.2022-0124oc Zobrazit plný text záznamu