Evaluating several biomarkers as predictors of aortic stiffness in young and older Africans, not consuming alcohol based on self-report
| Autor: | Aletta E. Schutte, Johannes M. Van Rooyen, Carla M.T. Fourie, Melissa Maritz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Black People Disease 030204 cardiovascular system & hematology 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Endocrinology Risk Factors Surveys and Questionnaires Diabetes mellitus Internal medicine Epidemiology Internal Medicine Humans Medicine Longitudinal Studies 030212 general & internal medicine Risk factor Prospective cohort study Pulse wave velocity Aged Aged 80 and over business.industry Public health General Medicine Middle Aged medicine.disease Female Aortic stiffness Self Report business Biomarkers |
| Zdroj: | Diabetes Research and Clinical Practice. 142:312-320 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2018.05.048 |
| Popis: | Aims Black populations from sub-Saharan Africa have a high prevalence of cardiovascular disease, which places significant strain on public health systems. Aortic stiffness is a prominent risk factor for cardiovascular disease development. We reported earlier that excessive alcohol use predicts aortic stiffness. However, we require a better understanding of other biomarkers involved in stiffness development, beyond alcohol use. Therefore, we determined which biomarkers (metabolic, inflammatory, endothelial activation and oxidative stress) relate to aortic stiffness in young and older black South Africans, self-reporting no alcohol-use. Methods We included cross-sectional data from young (aged 24.7 ± 3.24 years) black adults participating in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension (African-PREDICT) study (N = 216), and five-year follow-up data from older (aged 61.6 ± 9.77 years) black adults (N = 322) participating in the South African leg of the Prospective Urban and Rural Epidemiology study, conducted in the North West Province (PURE-SA-NWP). We excluded all participants self-reporting alcohol use. We determined biomarkers from blood samples, and measured carotid-femoral pulse wave velocity (PWV). Results Of all biomarkers investigated in multivariable-adjusted regression analyses, only plasma glucose (R2 = 0.24, β = 0.21, p Conclusion Dysglycaemia independently predicted aortic stiffness after five years in older black adults. Life-course management of body weight and sugar intake are important in preventing early vascular ageing and subsequent cardiovascular disease development in Africa. |
| Databáze: | OpenAIRE |
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