Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population
| Autor: | Jun Zhang, Xingmei Yao, Xiaoyi Guo, Shengxiang Ge, Han Wang, Ting Wu, Caihong Liang, Qiaoqiao Song, Zhao-Feng Bi, Tingdong Li, Jiangding Wang, Lingxian Qiu, Huan Yu, Caihong Li, Chunlan Zhuang, Yue Huang, Jiabao Tang, Yingying Su |
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| Rok vydání: | 2021 |
| Předmět: |
Human cytomegalovirus
Adult Pediatrics medicine.medical_specialty China Epidemiology Immunology prevalence Congenital cytomegalovirus infection Cytomegalovirus Antibodies Viral Microbiology Young Adult Pregnancy Seroepidemiologic Studies Virology Drug Discovery medicine Seroprevalence Humans Prospective Studies Pregnancy Complications Infectious Chinese population seroprevalence business.industry Early gestation Infant Newborn virus diseases Medical practice General Medicine medicine.disease Infectious Disease Transmission Vertical congenital infection Infectious Diseases Immunoglobulin G Cytomegalovirus Infections DNA Viral Parasitology Original Article Female business pregnant women Research Article |
| Zdroj: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| DOI: | 10.6084/m9.figshare.16617053.v1 |
| Popis: | Background Congenital human cytomegalovirus (CMV) infection remains largely unrecognized and underemphasized in medical practice. This study aimed to describe the maternal CMV seroprevalence rate in early gestation and congenital CMV infection in a Chinese population. Methods This prospective cohort study was conducted in three hospitals in China from 2015 through 2018. Pregnant women were enrolled in early gestation and followed up in middle and late gestation with serological testing. CMV serostatus was determined by IgG testing in serum during early gestation. Their newborns were screened for cCMV infection by PCR testing in both saliva and urine at two time points. The cCMV prevalence, maternal seroprevalence and associated factors were analyzed. Results In China, the CMV seroprevalence was 98.11% (6602/6729, 95% CI: 97.76%–98.41%), and the cCMV prevalence was 1.32% (84/6350, 95% CI: 1.07%–1.64%). Over 98% of cCMV-positive newborns were from pregnant women who were seropositive in early gestation in China. The prevalence of cCMV infection in newborns from seropositive and seronegative pregnant women was similar (crude prevalence: 1.33% vs 0.82%, P = 1.00; estimated prevalence: 1.27% vs 1.05%, P = 0.32). Pregnant women who were under 25 years old or primiparous had a lower seroprevalence. Newborns from pregnant women under 25 years old or from twin pregnancies had a higher prevalence of cCMV infection. Conclusion in China, the cCMV prevalence was high, and the rates were similar in newborns from pregnant women who were seropositive and seronegative in early gestation. The vast majority of cCMV newborns were from seropositive mothers. Trial registration:ClinicalTrials.gov identifier: NCT02645396.. |
| Databáze: | OpenAIRE |
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