Heterogeneity of peripheral blood monocytes, endothelial dysfunction and subclinical atherosclerosis in patients with Systemic Lupus Erythematosus
| Autor: | Tomasz Sliwa, Dominik Skiba, Bogdan Batko, M Krezelok, Tomasz Mikolajczyk, Tomasz J. Guzik, Juliusz Pryjma, Grzegorz Osmenda, Grzegorz Wilk |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Carotid Artery Diseases
Male Brachial Artery SLE Lipopolysaccharide Receptors 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Monocytes 0302 clinical medicine Risk Factors Lupus Erythematosus Systemic flow-mediated dilation Endothelial dysfunction Brachial artery Middle Aged Flow Cytometry Phenotype Vasodilation Carotid Arteries Cardiology Female Adult medicine.medical_specialty CD14 CD16 GPI-Linked Proteins Article 03 medical and health sciences Young Adult monocyte subsets Rheumatology Predictive Value of Tests Internal medicine medicine.artery medicine Humans intima-media thickness Aged 030203 arthritis & rheumatology Lupus erythematosus business.industry Receptors IgG medicine.disease Atherosclerosis Intima-media thickness Subclinical atherosclerosis Case-Control Studies Immunology Asymptomatic Diseases Endothelium Vascular business Biomarkers |
| Popis: | Background Systemic lupus erythematosus (SLE) is characterized by increased cardiovascular morbidity and mortality. SLE patients have increased prevalence of subclinical atherosclerosis, although the mechanisms of this observation remain unclear. Considering the emerging role of monocytes in atherosclerosis, we aimed to investigate the relationship between subclinical atherosclerosis, endothelial dysfunction and the phenotype of peripheral blood monocytes in SLE patients. Methods We characterized the phenotype of monocyte subsets defined by the expression of CD14 and CD16 in 42 patients with SLE and 42 non-SLE controls. Using ultrasonography, intima-media thickness (IMT) of carotid arteries and brachial artery flow-mediated dilation (FMD) as well as nitroglycerin-induced dilation (NMD) were assessed. Results Patients with SLE had significantly, but only modestly, increased IMT when compared with non-SLE controls (median (25th/75th percentile) 0.65 (0.60/0.71) mm vs 0.60 (0.56/0.68) mm; p Conclusions Our observations suggest that CD14dimCD16+monocytes are associated with subclinical atherosclerosis in SLE, although the mechanism appears to be independent of endothelial dysfunction. |
| Databáze: | OpenAIRE |
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