A predictive model for obstructive sleep apnea and Down syndrome
| Autor: | Yasas S. N. Jayaratne, Marco Muselli, Gil S. Weintraub, Eric A. Macklin, Richard A. Bruun, Brian G. Skotko, David Gozal, Dennis Rosen, Lauren Voelz, Veerasathpurush Allareddy, Emily Davidson, Mary Ellen McDonough, Nicholas Ching |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Medication history Polysomnography Down syndrome medicine.medical_treatment Polysomnogram Physical examination Severity of Illness Index Article Machine Learning Young Adult 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires 030225 pediatrics Outpatients Genetics medicine Humans Outpatient clinic Prospective Studies Sleep study Continuous positive airway pressure Child obstructive sleep apnea Genetics (clinical) Sleep Apnea Obstructive Models Statistical medicine.diagnostic_test business.industry Apnea medicine.disease trisomy 21 Obstructive sleep apnea Child Preschool Female medicine.symptom Sleep business 030217 neurology & neurosurgery |
| Zdroj: | American journal of medical genetics. Part A 173 (2017): 889–896. doi:10.1002/ajmg.a.38137 info:cnr-pdr/source/autori:Skotko, Brian G.; Macklin, Eric A.; Muselli, Marco; Voelz, Lauren; McDonough, Mary Ellen; Davidson, Emily; Allareddy, Veerasathpurush; Jayaratne, Yasas S. N.; Bruun, Richard; Ching, Nicholas; Weintraub, Gil; Gozal, David; Rosen, Dennis/titolo:A predictive model for obstructive sleep apnea and Down syndrome/doi:10.1002%2Fajmg.a.38137/rivista:American journal of medical genetics. Part A/anno:2017/pagina_da:889/pagina_a:896/intervallo_pagine:889–896/volume:173 Am J Med Genet A |
| ISSN: | 1552-4825 |
| DOI: | 10.1002/ajmg.a.38137 |
| Popis: | Obstructive sleep apnea (OSA) occurs frequently in people with Down syndrome (DS) with reported prevalences ranging between 55% and 97%, compared to 1–4% in the neurotypical pediatric population. Sleep studies are often uncomfortable, costly, and poorly tolerated by individuals with DS. The objective of this study was to construct a tool to identify individuals with DS unlikely to have moderate or severe sleep OSA and in whom sleep studies might offer little benefit. An observational, prospective cohort study was performed in an outpatient clinic and overnight sleep study center with 130 DS patients, ages 3–24 years. Exclusion criteria included previous adenoid and/or tonsil removal, a sleep study within the past 6 months, or being treated for apnea with continuous positive airway pressure. This study involved a physical examination/medical history, lateral cephalogram, 3D photograph, validated sleep questionnaires, an overnight polysomnogram, and urine samples. The main outcome measure was the apnea-hypopnea index. Using a Logic Learning Machine, the best model had a cross-validated negative predictive value of 73% for mild obstructive sleep apnea and 90% for moderate or severe obstructive sleep apnea; positive predictive values were 55% and 25%, respectively. The model included variables from survey questions, medication history, anthropometric measurements, vital signs, patient’s age, and physical examination findings. With simple procedures that can be collected at minimal cost, the proposed model could predict which patients with DS were unlikely to have moderate to severe obstructive sleep apnea and thus may not need a diagnostic sleep study. |
| Databáze: | OpenAIRE |
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