Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine

Autor:	Takuji Maekawa, Koji Sumikawa, Kazuyuki Sakai, Itsuko Shibata, Osamu Yoshitomi, Sungsam Cho
Rok vydání:	2012
Předmět:	Male medicine.medical_specialty Cardiotonic Agents Time Factors Swine Hydrogen gas Ischemia Myocardial Infarction chemistry.chemical_element Infarction Myocardial Reperfusion Injury Anterior Descending Coronary Artery Oxygen Ventricular Function Left Internal medicine Occlusion Administration Inhalation medicine Ventricular Pressure Animals cardiovascular diseases Myocardial infarction Myocardial Stunning Myocardial stunning Inhalation business.industry Myocardium medicine.disease Myocardial Contraction Disease Models Animal chemistry Anesthesia Cardiology Female Gases Cardiology and Cardiovascular Medicine business Hydrogen
Zdroj:	Scandinavian cardiovascular journal : SCJ. 46(3)
ISSN:	1651-2006
Popis:	Objectives. The present study was carried out to determine whether inhalation of hydrogen (H 2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H 2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H 2 plus 98% oxygen. Group E inhaled 4% H 2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74±13 (mean ± SD) %, which was significantly higher than that in group A (48±15%). Myocardial infarct size in group E (32±10%), but not in group D (40±9%) was smaller than that in group C (46±6%). Conclusions. Inhalation of 2% H 2 gas improves myocardial stunning, and inhalation of 4% but not 2% H 2 gas reduces myocardial infarct size in swine. Scandinavian Cardiovascular Journal, 46(3), pp.183-188; 2012
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac17acb2c062a49a46c22e645fd4423 https://pubmed.ncbi.nlm.nih.gov/22263852 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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