ADAM23 promotes neuronal differentiation of human neural progenitor cells
| Autor: | Andreas Wree, Susanne Seemann, Oliver Schmitt, Dirk Koczan, Arndt Rolfs, Mathias Ernst, Georg Fuellen, Annett Markus-Koch, Jiankai Luo, Jan Lukas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neurite Neurogenesis ADAM23 Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Neural Stem Cells Neurite growth medicine Humans lcsh:QH573-671 Molecular Biology hNPC lcsh:Cytology Microarray analysis techniques Research Cell Biology Neuron Embryonic stem cell Neural stem cell Cell biology ADAM Proteins 030104 developmental biology medicine.anatomical_structure Apoptosis Differentiation Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cellular & Molecular Biology Letters Cellular & Molecular Biology Letters, Vol 22, Iss 1, Pp 1-13 (2017) |
| ISSN: | 1689-1392 |
| Popis: | Background ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. Results In this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor cells (hNPCs). Upregulation of ADAM23 in hNPCs was found to increase the number of neurons and the length of neurite, while its downregulation decreases them and triggers cell apoptosis. RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- or downregulation of ADAM23. Conclusions Our results suggest that ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during hNPC differentiation. Electronic supplementary material The online version of this article (doi:10.1186/s11658-017-0045-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink