Evaluation of periodontal status and cytokine levels in saliva and gingival crevicular fluid of patients with inflammatory bowel diseases

Autor: Enver, Ayaz, Ozmeric, Nurdan, Isler, Sila Cagri, Toruner, Murat, Fidan, Cigdem, Demirci, Gulsah, Elgun, Serenay, DA Silva, Andre Paes B
Rok vydání: 2022
Předmět:
Zdroj: Enver, Ayaz; Ozmeric, Nurdan; Isler, Sila Cagri; Toruner, Murat; Fidan, Cigdem; Demirci, Gulsah; Elgun, Serenay; DA Silva, Andre Paes B (2022). An Evaluation of Periodontal Status and Cytokine Levels in Saliva and Gingival Crevicular Fluid of Patients with Inflammatory Bowel Diseases. Journal of periodontology, 93(11), pp. 1649-1660. Wiley 10.1002/JPER.22-0065
ISSN: 1943-3670
0022-3492
DOI: 10.1002/jper.22-0065
Popis: AIMS Periodontal diseases and inflammatory bowel diseases (IBD, ulcerative colitis [UC] and Crohn's disease [CD]) have been reported to present with increased salivary and gingival crevicular fluid (GCF) concentrations of cytokines. The aim of this study was to evaluate the salivary and GCF levels of TNF-α, IL-1β, IL-10, and IL-17A and their associations with the periodontal statuses of UC, CD and non-IBD patients, and to analyze the interrelationships among these cytokines, IBD conditions, and periodontal diseases. MATERIALS AND METHODS This cross-sectional study was performed with a total of 131 patients (62 women and 69 men, mean age 42.96±13.02 years). Patients were divided into three groups: UC, CD, and non-IBD. Periodontal status was defined according to the 2017 World Workshop Disease Classification. Salivary and GCF cytokine levels were analyzed using ELISA. RESULTS UC and CD patients diagnosed as having periodontitis and gingivitis presented with significantly higher levels of TNF-α and lower levels of IL-10 as compared with non-IBD patients (p
Databáze: OpenAIRE
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