Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression

Autor:	Michael Hughes, Joseph Makhema, Oganne Batlang, Maureen Sakoi, Kara Bennett, Pilar Garcia-Broncano, Shahin Lockman, Daniel R. Kuritzkes, Kenneth Maswabi, Roger L. Shapiro, Patrick Jean-Philippe, Mathias Lichterfeld, Sikhulile Moyo, Terrence Mohammed, Gbolahan Ajibola
Rok vydání:	2021
Předmět:	0301 basic medicine Microbiology (medical) medicine.medical_specialty Sustained Virologic Response DNA polymerase Human immunodeficiency virus (HIV) HIV Infections Viremia medicine.disease_cause Peripheral blood mononuclear cell Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Viral suppression Child Online Only Articles Whole blood biology business.industry HIV Viral Load medicine.disease 030104 developmental biology Infectious Diseases chemistry DNA Viral Leukocytes Mononuclear biology.protein RNA Viral business Serostatus DNA
Zdroj:	Clin Infect Dis
ISSN:	1537-6591 1058-4838
DOI:	10.1093/cid/ciab143
Popis:	Background The impact of very early infant treatment on human immunodeficiency virus (HIV) reservoir, and markers for treatment success, require study. Methods The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV started on antiretroviral treatment (ART) at Results Median quantitative cell-associated DNA after at least 84 weeks was significantly lower among the first 27 EIT children tested than among 10 controls (40.8 vs 981.4 copies/million cells; P Conclusions Lower viral reservoir was associated with starting ART at
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abf3b5b3f3fb9791950bd0178aec818 https://doi.org/10.1093/cid/ciab143 Zobrazit plný text záznamu