Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence
| Autor: | Philip R. Szeszko, G. Paul Amminger, Berko Milleit, Cornelia Wiegand, Toshikazu Ikuta, Pamela DeRosse, Robert K. McNamara, Stefan Smesny, Uta-Christina Hipler, Jana Hesse, Bart D. Peters, Anil K. Malhotra, Frédéric M. Vaz |
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| Přispěvatelé: | Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Phospholipase A biology General Neuroscience Fatty acid Phospholipase White matter 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Phospholipase A2 Biochemistry chemistry Docosahexaenoic acid Internal medicine Fractional anisotropy medicine biology.protein lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery Polyunsaturated fatty acid |
| Zdroj: | Neuroscience, 343, 423-433. Elsevier Limited |
| ISSN: | 0306-4522 |
| Popis: | Adolescence is a period of major brain white matter (WM) changes, and membrane lipid metabolism likely plays a critical role in brain WM myelination. Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential components of cell membranes including oligodendrocytes, and LC-PUFA release and turnover in membranes is regulated by phospholipase A 2 enzymes. To investigate the role of membrane lipid metabolism in healthy WM myelination across adolescence, the present study examined the relationship between membrane LC-PUFA biostatus, phospholipase A 2 activity, and brain WM microstructure in healthy subjects aged 9–20 years ( n = 30). Diffusion tensor imaging (DTI) was performed to measure average fractional anisotropy (FA) and diffusivity (indices sensitive to WM myelination) of nine major cerebral WM tracts. Blood samples were collected to measure erythrocyte membrane fatty acid concentrations and plasma intracellular phospholipase A 2 activity ( in PLA 2 ). Plasma in PLA 2 activity showed a significant U-curved association with WM radial diffusivity, and an inverted U-curved association with WM FA, independent of age. A significant positive linear correlation was observed between docosahexaenoic acid concentration and axial diffusivity in the corpus callosum. These findings suggest that there may be optimal physiological in PLA 2 activity levels associated with healthy WM myelination in late childhood and adolescence. Myelination may be mediated by cleavage of docosahexaenoic acid from membrane phospholipids by in PLA 2 . These findings have implications for our understanding of the role of LC-PUFA homeostasis in myelin-related neurodevelopmental disorders. |
| Databáze: | OpenAIRE |
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