Low density lipoprotein particle size in hypopituitary adults receiving conventional hormone replacement therapy
| Autor: | Frank P. Alford, James D. Best, F. L. Hew, Glenn M. Ward, Ken Sikaris, David N O'Neal |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Biochemistry Hypopituitarism Body Mass Index chemistry.chemical_compound Endocrinology Insulin resistance High-density lipoprotein Internal medicine medicine Humans Particle Size education Triglycerides Aged Apolipoproteins B education.field_of_study Apolipoprotein A-I Cholesterol Cholesterol HDL Biochemistry (medical) Middle Aged medicine.disease Lipoproteins LDL chemistry Low-density lipoprotein Female lipids (amino acids peptides and proteins) Low-density lipoprotein particle Body mass index Lipoprotein |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 81:2448-2454 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.81.7.8675559 |
| Popis: | Adults receiving conventional replacement therapy for hypopituitarism are known to have increased cardiovascular mortality. The aim of this study was to assess the lipid profiles of 30 hypopituitary adults compared with 2 case control groups, 1 matched for age, sex, and body mass index (BMI) and the second matched for age and sex only with a BMI representative of the general population. Fasting lipids, lipoproteins, and apoproteins (Apo) were determined by routine methods. Low density lipoprotein (LDL) particle size was determined by nondenaturing gradient gel electrophoresis. LDL size was significantly smaller in the hypopituitary group (25.9 +/- 0.1 nm) than in the BMI-matched (26.2 +/- 0.1 nm; P0.05) and standard control (26.3 +/- 0.1 nm; P0.01) groups. High density lipoprotein cholesterol levels in the hypopituitary group were significantly lower than those in the BMI-matched control group (1.13 +/- 0.06 vs. 1.34 +/- 0.06 mmol/L; P0.05) and the standard control group (1.38 +/- 0.06 mmol/L; P0.005). Apo A1 levels were also lower compared with those in the BMI-matched (122 +/- 6 vs. 137 +/- 4 mg/dL; P0.05) and the standard (143 +/- 4 mg/dL; P0.005) control groups. There was a trend toward higher triglyceride levels when the hypopituitary subjects were compared with the standard control group [1.4 (95% CI, 1.3-2.2) vs. 1.0 (95% CI, 0.9-1.4) mmol/L; P = 0.06]. These differences were more marked in the female subjects studied. No significant differences were noted in total cholesterol, LDL cholesterol, or Apo B levels. We conclude that hypopituitary patients receiving conventional replacement therapy have an atherogenic lipid profile characterized by small dense LDL, decreased high density lipoprotein cholesterol, and increased triglyceride levels, which may contribute to the excess cardiovascular mortality in this group. |
| Databáze: | OpenAIRE |
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