Innovative Skin Product Emulsions with Enhanced Antioxidant, Antimicrobial and UV Protection Properties Containing Nanoparticles of Pure and Modified Chitosan with Encapsulated Fresh Pomegranate Juice
| Autor: | Souzan Vergkizi-Nikolakaki, Dimitra A. Lambropoulou, Evi Christodoulou, Georgia Michailidou, Nikolaos D Bikiaris, Smaro Lykidou, Anna Ofrydopoulou, Nikolaos Nikolaidis, Eleni Gounari, Maria Lazaridou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
antimicrobial properties
Polymers and Plastics Biocompatibility Electrospray ionization Nanoparticle 02 engineering and technology Article Chitosan lcsh:QD241-441 chemistry.chemical_compound Crystallinity 0404 agricultural biotechnology Dynamic light scattering lcsh:Organic chemistry UV protection Chemistry chitosan derivatives Chemical modification 04 agricultural and veterinary sciences General Chemistry 021001 nanoscience & nanotechnology 040401 food science Ammonium hydroxide cosmetic emulsions pomegranate juice polysaccharide antioxidant stability nanoparticles 0210 nano-technology Nuclear chemistry |
| Zdroj: | Polymers, Vol 12, Iss 1542, p 1542 (2020) Polymers Volume 12 Issue 7 |
| ISSN: | 2073-4360 |
| Popis: | In the present study, a chitosan (CS) derivative with the 2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SDAEM) zwitterionic monomer was prepared through chemical modification. The successful synthesis of CS-SDAEM was confirmed by Fourier-transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR) spectroscopies. Its crystallinity was studied by X-ray Diffraction (XRD), while in vitro cytotoxicity and cell viability assays established its biocompatibility. Filtered fresh pomegranate juice (PJ) was loaded in nanoparticles of neat CS and its derivative via ionic gelation method. Dynamic Light Scattering (DLS) revealed nanoparticles sizes varying between 426 nm and 4.5 &mu m, indicating a size-dependence on the polymer concentration used during encapsulation. High-performance liquid chromatography coupled with photodiode array and electrospray ionization mass spectrometry detection (LC-PDA-ESI/MS) revealed that PJ active compounds were successfully and in sufficient amounts encapsulated in the nanoparticles interior, whereas XRD indicated a crystalline structure alteration after nanoencapsulation. The resulted PJ-loaded nanoparticles were further utilized for the preparation of innovative O/W cosmetic emulsions. All produced emulsions exhibited good pH and viscosity stability for up to 90 days, while the sun protection factor (SPF) was enhanced due to the presence of the PJ. Enhanced antioxidant and antimicrobial properties due to the phenolic compounds of PJ were also observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|