The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study

Autor: Anni Lehikoinen, Seppo Heinonen, Raimo Voutilainen, Jarkko Romppanen
Přispěvatelé: HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Helsinki University Hospital Area, University of Helsinki
Jazyk: angličtina
Rok vydání: 2020
Předmět:
free beta-hCG
Alcohol
First trimester screening
PLASMA-PROTEIN-A
Cohort Studies
chemistry.chemical_compound
small for gestational age
0302 clinical medicine
3123 Gynaecology and paediatrics
Pregnancy
Prenatal Diagnosis
Pregnancy-Associated Plasma Protein-A
Chorionic Gonadotropin
beta Subunit
Human
030212 general & internal medicine
nuchal translucency
030219 obstetrics & reproductive medicine
Obstetrics
alcohol
Obstetrics and Gynecology
Substance abuse
Alcoholism
Gestation
Female
Nuchal Translucency Measurement
Research Article
Adult
medicine.medical_specialty
Substance-Related Disorders
BIOMARKERS
Reproductive medicine
BETA
lcsh:Gynecology and obstetrics
smoking
03 medical and health sciences
Young Adult
HUMAN CHORIONIC-GONADOTROPIN
ETHANOL
medicine
Humans
EXPOSURE
BIOCHEMICAL MARKERS
lcsh:RG1-991
Retrospective Studies
Fetus
business.industry
Retrospective cohort study
medicine.disease
free β-hCG
Pregnancy Complications
Pregnancy Trimester
First
chemistry
Small for gestational age
PAPP-A
business
Trisomy
Zdroj: BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Pregnancy and Childbirth
ISSN: 1471-2393
Popis: Background The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. Methods A routine combined FTS including measurements of maternal serum levels of free β-human chorionic gonadotropin subunit (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9–11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11–13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. Results Free β-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P = 0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free β-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P = 0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P Conclusions The present study shows increased free β-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free β-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls.
Databáze: OpenAIRE
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