Renal Dysfunction in Glomerulonephropathy Associated with Rapid Onset Renal Failure
| Autor: | D. Watana, Visith Sitprija, Rachanee Sensirivatana, Yenrudi S, Pochanugool C, Narisa Futrakul, Makumkrong Poshyachinda, V. Singkhwa, Futrakul P |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Renal Plasma Flow Adolescent Urology Hemodynamics Renal function Angiotensin-Converting Enzyme Inhibitors Anuria Kidney urologic and male genital diseases Critical Care and Intensive Care Medicine Glomerulonephritis Oliguria Internal medicine medicine Humans Child Heparin urogenital system business.industry Anticoagulants Dipyridamole General Medicine Acute Kidney Injury Cilazapril Calcium Channel Blockers medicine.disease Treatment Outcome Endocrinology medicine.anatomical_structure Nephrology Child Preschool Renal blood flow Drug Therapy Combination Vascular Resistance Isradipine medicine.symptom business Tubulointerstitial Disease Blood Flow Velocity Platelet Aggregation Inhibitors Glomerular Filtration Rate Kidney disease |
| Zdroj: | Renal Failure. 19:77-84 |
| ISSN: | 1525-6049 0886-022X |
| DOI: | 10.3109/08860229709026262 |
| Popis: | Eight patients between the ages of 5 and 26 years developed a rapid decline of renal function with a period of oliguria or anuria which ranged between 1 and 21 days. The initial assessment of renal function revealed a severe degree of glomerular, tubular, and vascular abnormalities. The magnitude of the renal dysfunction was quantified and expressed in terms of a clinical score. The degree of glomerular and tubular dysfunction was inversely proportional to the renal plasma flow and peritubular capillary blood flow, respectively. Similar findings have been observed in a variety of other glomerulonephropathies where a relationship exists between the reduction of peritubular capillary blood flow and the severity of the tubulointerstitial disease. Evidence to support the position that the reduction of peritubular capillary blood flow plays a primary role in inducing tubulointerstitial disease is as follows: (i) A reduction of peritubular capillary blood flow has been documented in mesangial proliferative nephrosis with steroid resistance prior to the detection of tubulointerstitial disease. (ii) Ischemic insults are capable of inducing tubulointerstitial disease in the experimental setting of renal artery occlusion in animals. (iii) As demonstrated in the present report, an improvement of tubular function can be achieved following an increase in peritubular capillary blood flow with therapy designed to enhance renal perfusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|