New caffeoyl derivatives from Elephantopus scaber
| Autor: | Zhong-Mei Zou, Shi-Shan Yu, Hai Shang, Di Pei, Tao Zhang, Ling-Yu Li, Hong-Mei Jia, Meng Yu, Hong-Wu Zhang, Lu Fu |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
biology Lipopolysaccharide medicine.drug_class Organic Chemistry Pharmaceutical Science General Medicine Asteraceae biology.organism_classification Nmr data Elephantopus scaber Anti-inflammatory Analytical Chemistry Nitric oxide chemistry.chemical_compound Complementary and alternative medicine chemistry Biochemistry Drug Discovery Ic50 values medicine Molecular Medicine Tumor necrosis factor alpha |
| Zdroj: | Journal of Asian Natural Products Research. 24:713-721 |
| ISSN: | 1477-2213 1028-6020 |
| Popis: | Three new caffeoyl derivatives (1–3), together with two known ones (4–5), were isolated from the whole plant of Elephantopus scaber Linn. The structures of the new compounds were elucidated using detailed spectroscopic analysis. Compound 4 was obtained and its NMR data were given for the first time. All isolates were evaluated for their anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and pro-inflammatory cytokines release in RAW 264.7 cells. Compounds 2–5 showed mild inhibitory activities with IC50 values ranging from 64.78 to 87.21 μM, and 3–4 could inhibit LPS-induced tumor necrosis factor-α (TNF-α) production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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