Chronic magnesium deficiency and human disease; time for reappraisal?
| Autor: | A A Ismail, Yusof Ismail, A A A Ismail |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Nutritional Status Physiology chemistry.chemical_element 030204 cardiovascular system & hematology Recommended Dietary Allowances Bone health Magnesium urine Hypomagnesemia 03 medical and health sciences 0302 clinical medicine Human disease Risk Factors Magnesium deficiency (medicine) Epidemiology medicine Humans Magnesium 030212 general & internal medicine business.industry Magnesium blood General Medicine medicine.disease chemistry Chronic Disease Dietary Supplements business Magnesium Deficiency |
| Zdroj: | QJM: An International Journal of Medicine. 111:759-763 |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcx186 |
| Popis: | Numerous epidemiological, experimental and clinical studies over the last 30 years have consistently shown that chronic magnesium deficiency is associated with and/or exacerbates a number of major disorders (Table 1). Yet chronic magnesium deficiency is not widely recognized and a major reason for this failure is that serum magnesium levels do not accurately reflect body magnesium stores. Specifically, in chronic magnesium deficiency, serum magnesium levels are often within the normal reference range (usually lowest quartile) and may not progress to overt hypomagnesaemia. This raises serious questions namely (i) should chronic magnesium deficiency be considered in high-risk patients irrespective of serum magnesium, even when 'normal'? and (ii) if recognized, should oral magnesium supplement be given to restore body stores? Appreciating the vital role of magnesium for normal cellular function and bone health may help in formulating a well-considered and justifiable approach to these questions. Pragmatic tests for assessing magnesium status in the adult are suggested and discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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