AntibactERial Activity of Four Cephalosporins in an ExpERimental Infection in Relation to In Vitro Effect and Pharmacokinetics
| Autor: | A. M. van Dokkum, Herman Mattie, L. Brus-Weijer, E. van Strijen, A. M. Krul |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.drug_class
Antibiotics Cephalosporin Ceftazidime Biology Microbiology Mice In vivo Escherichia coli medicine Animals Immunology and Allergy Cefamandole Escherichia coli Infections Antibacterial agent Cefuroxime Ceftriaxone Cephalosporins Klebsiella Infections Specific Pathogen-Free Organisms Disease Models Animal Klebsiella pneumoniae Infectious Diseases Agranulocytosis Protein Binding medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 162:717-722 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/162.3.717 |
| Popis: | The in vitro activity of four cephalosporins was compared with their effects in an experimental thigh infection (cefuroxime and cefamandole against Escherichia coli and cefamandole, ceftriaxone, and ceftazidime against Klebsiella pneumoniae) in granulocytopenic mice. The effect in vitro (ER) was defined as the difference between the growth rate without antibiotic and the growth rate at the steepest part of a 3-h growth curve in the presence of an antibiotic. The relation between concentration and ER was described with the Hill equation. Using pharmacokinetic parameters of the plasma concentrations in vivo and those of the Hill equation the corresponding time course of ER was calculated and by integration with respect to time (0tERdt), an estimate was obtained of the effect on bacteria. For all four antibiotics this estimate was significantly correlated with the actual values of the effect in vivo (EN), defined as the difference in numbers of bacteria between controls and antibiotic-treated animals at 4 h. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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