Current trends on bioengineering approaches for ovarian microenvironment reconstruction
| Autor: | Gustavo Henrique Doná Rodrigues Almeida, Rebeca Piatniczka Iglesia, Jaqueline de Carvalho Rinaldi, Mikaelly Kiemy Murai, Celso Vitor Alves Queiroz Calomeno, Leandro Norberto da Silva Junior, Bianca de Oliveira Horvath-Pereira, Letícia Beatriz Mazo Pinho, Maria Angelica Miglino, Ana Claudia Oliveira Carreira |
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| Rok vydání: | 2022 |
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| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Ovarian tissue has a unique microarchitecture and a complex cellular and molecular dynamics that are essential for follicular survival and development. Due to this great complexity, several factors may lead to ovarian insufficiency, and therefore to systemic metabolic disorders and female infertility. Techniques currently used in the reproductive clinic such as oocyte cryopreservation or even ovarian tissue transplant, although effective, have several limitations, which impairs their wide application. In this scenario, mimetic ovarian tissue reconstruction comes as an innovative alternative to develop new methodologies for germ cells preservation and ovarian functions restoration. The ovarian ECM is crucial for oocyte viability maintenance, once acts actively in folliculogenesis. One of the key components of ovarian bioengineering is biomaterials application that mimic extracellular matrix (ECM) and provide conditions for cell anchorage, proliferation and differentiation. Therefore, this review aims to describe ovarian tissue engineering approaches and list the main limitations of current methods for preservation and reestablishment of ovarian fertility. In addition, we describe the main elements that structure this study field, highlighting the main advances and the challenges to overcome to develop innovative methodologies to be applied in reproductive medicine. |
| Databáze: | OpenAIRE |
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