HRCT in cystic fibrosis in patients with CFTR I1234V mutation: Assessment of scoring systems with low dose technique using multidetector system and correlation with pulmonary function tests
| Autor: | Kailash C Garg, Atiqa Abdul Wahab, Ibrahim A. Janahi, Venkatraman Bhat, Rajvir Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
High-resolution computed tomography Bronchiectasis medicine.diagnostic_test business.industry Intraclass correlation Chest Radiology high-resolution computed tomography R895-920 medicine.disease Spearman's rank correlation coefficient Cystic fibrosis Surgery Pulmonary function testing Correlation cystic fibrosis Medical physics. Medical radiology. Nuclear medicine medicine HRCT low-dose CT Radiology Nuclear Medicine and imaging In patient Radiology business CFTR I1234V mutation |
| Zdroj: | The Indian Journal of Radiology & Imaging Indian Journal of Radiology and Imaging, Vol 25, Iss 01, Pp 44-51 (2015) |
| ISSN: | 1998-3808 0971-3026 |
| Popis: | Background and Aims: Pulmonary changes in patients with cystic fibrosis (CF) with CFTR I1234V mutation have not been extensively documented. Impact of geographic influence on phenotypical expression is largely unknown. This descriptive clinical study presents the high-resolution computed tomography (HRCT) pulmonary findings and computed tomography (CT) scoring with respect to pulmonary function tests (PFT) in a small subset of CF group. Materials and Methods: We examined 29 patients between 2 and 31 years of age with CFTR I1234V mutation. HRCT and PFT were performed within 2 weeks of each other. Imaging abnormalities on HRCT were documented and analyzed by utilizing the scoring system described by Bhalla et al., Brody et al., Helbich et al.,and Santamaria et al. Efficacy of the scoring system with respect to PFT was compared. Statistical Analysis: Inter-observer reliability of the scoring systems was tested using intraclass correlation (ICC) between the two observers. Spearman correlation coefficients were calculated between the scoring systems and between the scoring systems and PFT results. Results: In our study, right upper and middle lobes were the most frequently involved sites of involvement. Bronchiectasis and peribronchial thickening were the most frequent imaging findings. Scores with all four scoring systems were reproducible, with good ICC coefficient of 0.69. There was good agreement between senior radiologists in all scoring systems. Conclusion: We noted pulmonary imaging abnormalities in a large majority (96%) of our CF patients. There was no significant difference in the CT scores observed from various systems. The CT evaluation system by Broody is detailed and time consuming, and is ideal for research and academic setup. On the other hand, the systems by Bhalla and Santamaria are easy to use, quick, and equally informative. We found the scoring system by Santamaria preferable over that of Bhalla by virtue of additional points of evaluation and ease of use, and therefore better suited for busy clinical practice. |
| Databáze: | OpenAIRE |
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