Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats
| Autor: | Manjunatha Sammeturi, Altaf Mohammad, Sasi Bhusana Rao Bongu, Althaf Hussain Shaik, Lakshmi Devi Kodidhela, Srinivasulu Cheemanapalli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine medicine.medical_specialty Aspartate transaminase Computational and Data Sciences 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound Syringic acid Isoprenaline Internal medicine medicine lcsh:QH301-705.5 ComputingMethodologies_COMPUTERGRAPHICS chemistry.chemical_classification biology Chemistry Glutathione peroxidase Isoproterenol Glutathione Myocardial infarction 030104 developmental biology Endocrinology Alanine transaminase lcsh:Biology (General) Resveratrol biology.protein Uric acid Creatine kinase General Agricultural and Biological Sciences 010606 plant biology & botany medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1429-1435 (2019) Saudi Journal of Biological Sciences |
| Popis: | Graphical abstract Objective To evaluate the cardio-protection of syringic acid (SA) in combination with resveratrol (RV) in isoproterenol (ISO) induced myocardial infarcted (MI) rats. Methods Groups of all rats were subjected oral pre-treatment at the beginning of the study with SA (50 mg/kg), RV (50 mg/kg) and combination (COMB) of SA (25 mg/kg) and RV (25 mg/kg) along with gallic acid (GA) (50 mg/kg) for 30 days. After sacrification, homogenate of heart tissue along with serum were utilized for further biochemical investigations. The effects on creatine kinase (CK), aspartate transaminase (AST), alanine transaminase (ALT) and gamma glutamyl transferase (GGT) were studied in serum and heart tissues. Glutathione-s-transferase (GST), glutathione peroxidase (GPX) and reduced glutathione (GSH), membrane bound enzymes and electrolytes were tested in heart tissues. Body weights and heart weights were also observed along with high sensitivity C-reactive protein (hs-CRP), uric acid and total protein content (TPC) in serum. Results CK, AST, ALT and GGT levels in serum were augmented significantly while these enzymes are decreased in cardiac tissue samples of ISO–treated rats. GST, GPX, GSH, Na+/K+, Mg2+, Ca2+ ATPases, K+ ions were significantly decreased while Na+ and Ca2+ ions were increased in the heart tissues of ISO-injected rats. Loss and gain of body and heart weights were noticed significantly in rats having ISO administration. ISO group showed significant increase in hs-CRP and Uric acid while significant decrease in TPC. All of actions of ISO were ameliorated by COMB. Conclusions COMB suppressed ISO induced MI in rats and exhibited cardio-protection. |
| Databáze: | OpenAIRE |
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