Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots
| Autor: | Anthony M. Ford, Britt Gustafsson, Gustaf Leijonhufvud, Kristin Mattsson, Gordana Bogdanovic, Kim Ramme, Emma Honkaniemi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Locus (genetics) Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Fusion gene 03 medical and health sciences Developmental timing 0302 clinical medicine hemic and lymphatic diseases Internal medicine Medicine Humans Child Paediatric patients Hematology business.industry T-cell acute lymphoblastic leukaemia Infant Newborn Intracellular Signaling Peptides and Proteins Infant Oncology 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Nested polymerase chain reaction 030215 immunology TAL1 |
| Zdroj: | Pediatric bloodcancer. 65(11) |
| ISSN: | 1545-5017 |
| Popis: | SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of the rearrangement is still unknown. To investigate whether the fusion gene can be detected in neonatal blood spots (NBSs) from paediatric patients diagnosed with T-cell ALL, we analysed DNA from 38 paediatric patients with T-ALL by nested polymerase chain reaction and electrophoresis. The STIL-TAL1 fusion gene was not detected in NBSs from any of the 38 patients with T-ALL, suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-ALL. |
| Databáze: | OpenAIRE |
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