Prospects for Immunotoxin Therapy in Cancer
| Autor: | G. Fathman, Arthur E. Frankel, L. L. Houston, B. F. Issell |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Antibodies
Neoplasm medicine.drug_class medicine.medical_treatment Bacterial Toxins Graft vs Host Disease Immunoglobulins Monoclonal antibody General Biochemistry Genetics and Molecular Biology Cell membrane Mice Immunotoxin Neoplasms medicine Animals Humans Moiety Cytotoxicity Cells Cultured Bone Marrow Transplantation Toxins Biological biology Antibodies Monoclonal Neoplasms Experimental General Medicine Immunotherapy Molecular biology In vitro medicine.anatomical_structure Biochemistry Immunoglobulin G biology.protein Female Antibody |
| Zdroj: | Annual Review of Medicine. 37:125-142 |
| ISSN: | 1545-326X 0066-4219 |
| DOI: | 10.1146/annurev.me.37.020186.001013 |
| Popis: | Immunotoxins are formed by chemically linking antibodies to "toxic" polypeptides that inactivate protein synthesis. These hybrid protein molecules are guided to tumor cells by the antibody moiety, and once bound to the tumor cells, the toxic polypeptide moiety penetrates the cell membrane and enzymatically inactivates protein synthesis. A stepwise approach to identifying the potential clinical uses of immunotoxins in cancer therapy is examined in this chapter. |
| Databáze: | OpenAIRE |
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