Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

Autor: Lucia de Noronha, Silvana Maris Cirio, Yorgos Luiz Santos de Salles Graça, Antônio Felipe Paulino de Figueiredo WouK, Osvaldo Malafaia, Claudia Turra PimpãoVII, Daniel Dantas Ferrarin, Jurandir Marcondes Ribas-Filho, Maria Fernanda Torres, Eros Luiz de Sousa, Carlos Hespanha Marinho Junior
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Time Factors
RD1-811
Thiazines
Neovascularization
Physiologic
Ileum
Anastomosis
Meloxicam
Collagen Type I
03 medical and health sciences
chemistry.chemical_compound
Random Allocation
0302 clinical medicine
Medicine
Animals
Cyclooxygenase Inhibitors
Postoperative Period
Rats
Wistar
Sirius Red
Collagen type
Wound Healing
business.industry
Anastomosis
Surgical
Anti-Inflammatory Agents
Non-Steroidal
Surgery
Vascular endothelial growth factor
Thiazoles
medicine.anatomical_structure
Collagen Type III
Receptors
Vascular Endothelial Growth Factor
chemistry
Matrix Metalloproteinase 9
030220 oncology & carcinogenesis
Anesthesia
Models
Animal
Morphine
Wound Healing. Intestine
030211 gastroenterology & hepatology
Small. Anti-Inflammatory Agents. Rats
business
Wound healing
medicine.drug
Zdroj: Acta Cirúrgica Brasileira v.31 n.5 2016
Acta Cirúrgica Brasileira
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
Acta Cirurgica Brasileira, Vol 31, Iss 5, Pp 320-326 (2016)
Acta Cirurgica Brasileira, Volume: 31, Issue: 5, Pages: 320-326, Published: MAY 2016
Popis: PURPOSE : To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. METHODS: Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. RESULTS: Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. CONCLUSION: The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Databáze: OpenAIRE
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