RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements
| Autor: | Fred K. Chen, Shehata Mohamed, Deepaysh D. C. S. Dutt, Alex Au Yong, Saumya Rajgopal, Alex Hansen, Sharaf Mohamed, Moreno Menghini, Noha Ali, Rumaanah Jeewa, Danuta M. Sampson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Optovue AngioVue split-spectrum amplitude decorrelation angiography Biomedical Engineering retinal capillary density optical coherence tomography angiography Retina Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vessel density Optical coherence tomography Ophthalmology medicine Humans Fluorescein Angiography medicine.diagnostic_test business.industry Limits of agreement Retinal Vessels Retinal Software upgrade Optical coherence tomography angiography Middle Aged normative data Retinal vessel 030104 developmental biology medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs OCTA business Software Tomography Optical Coherence |
| Zdroj: | Translational Vision Science & Technology |
| Popis: | Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods:OptovueOCTA images (3×3mm) from126 individuals (105healthy eyes and 72 eyes with retinal disease)were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively.Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software. |
| Databáze: | OpenAIRE |
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