Local nasal immunotherapy with extract in powder form is effective and safe in grass pollen rhinitis: A double-blind study
| Autor: | L. Andri, Giovanni Andri, Gabriella Dimitri, Gianenrico Senna, Paolo Mezzelani, Claudio Betteli, Paolo Falagiani, Silvana Givanni |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Allergy medicine.medical_specialty medicine.medical_treatment Immunology medicine.disease_cause Gastroenterology law.invention Radioallergosorbent Test Allergen Double-Blind Method Randomized controlled trial law Internal medicine Immunopathology Pollen otorhinolaryngologic diseases medicine Humans Immunology and Allergy Administration Intranasal Skin Tests business.industry Rhinitis Allergic Seasonal food and beverages Immunotherapy Allergens medicine.disease Desensitization Immunologic Hay fever Female Nasal administration business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 97:34-41 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/s0091-6749(96)70280-4 |
| Popis: | BACKGROUND: Local nasal immunotherapy has been studied, by means of an extract in powder form, in patients with allergic rhinitis caused by grass pollen. METHODS: Thirty-two patients allergic to grass were studied for 37 weeks in a double-blind controlled trial. Subjects were selected on the basis of a positive history, skin test result, RAST finding, and result of intranasal challenge to grass pollen. Two 16-patient groups were randomly assigned to active or placebo treatment. The treatment lasted 26 weeks (14 for the build-up phase, 12 for the maintenance period). RESULTS: No significant differences were observed in nasal symptoms during the treatment. During the pollen season the mean weekly symptom and medication scores were significantly lower in the treated group, compared with the control group, even considering each allergic symptom separately. Moreover, only in the treated group was a significant increase of specific nasal threshold to grass pollen observed after treatment. CONCLUSIONS: This study indicates that local nasal immunotherapy with allergen in powder form can be a suitable alternative to the traditional subcutaneous immunotherapy in terms of clinical efficacy and safety in grass-allergic rhinitis. (J ALLERGY CLIN IMMUNOL 1996;97:34-41.) |
| Databáze: | OpenAIRE |
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