Neurologic Manifestations of COVID-19 in Children: Emerging Pathophysiologic Insights
| Autor: | Andrew T. Pavia, John F. Bohnsack, Michelle E. Schober |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cerebrovascular Stroke
Pediatrics medicine.medical_specialty 2019-20 coronavirus outbreak pediatrics Coronavirus disease 2019 (COVID-19) viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCCM Concise Clinical Science Review Critical Care and Intensive Care Medicine neurologic manifestations Pandemic medicine Humans immunologic Neurologic disease Child child development SARS-CoV-2 business.industry COVID-19 Pathophysiology Pediatrics Perinatology and Child Health Nervous System Diseases Headaches medicine.symptom business |
| Zdroj: | Pediatric Critical Care Medicine |
| ISSN: | 1529-7535 |
| DOI: | 10.1097/pcc.0000000000002774 |
| Popis: | The COVID-19 pandemic has affected mortality and morbidity across all ages, including children. Neurologic manifestations of coronavirus disease 2019, ranging from headaches to cerebrovascular stroke, may involve the CNS or peripheral nervous system. Neurologic involvement is also noted in the multisystem inflammatory syndrome in children, a pediatric condition that occurs weeks after infection with severe acute respiratory syndrome coronavirus 2, the virus that causes COVID-19. Knowledge about mechanisms of neurologic disease and immunologic response to severe acute respiratory syndrome coronavirus 2 is scarce but rapidly growing. Here, we concisely review experimental and clinical data relevant to pathophysiologic hypotheses regarding neurologic manifestations of coronavirus disease 2019. We highlight important knowledge gaps in differences between adults and children in their response to coronavirus disease 2019. |
| Databáze: | OpenAIRE |
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