Cardiovascular Disease in Acromegaly
| Autor: | Morali D Sharma, Anh V Nguyen, Spandana Brown, Richard J. Robbins |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cardiomyopathy Diastole 030209 endocrinology & metabolism Disease 030204 cardiovascular system & hematology Cardiovascular System Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Acromegaly medicine Humans Insulin-Like Growth Factor I business.industry Human Growth Hormone valvular heart disease General Medicine Articles medicine.disease Prognosis Pathophysiology Cardiovascular Diseases Heart failure Cardiology business |
| Zdroj: | Methodist DeBakey cardiovascular journal. 13(2) |
| ISSN: | 1947-6108 |
| Popis: | In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications. |
| Databáze: | OpenAIRE |
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