Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
| Autor: | Ingrid C. Weel, Rebecca N. Baergen, Vera Borges, Mariana Romao-Veiga, Maria Terezinha Serrão Peraçoli, Steven S. Witkin, Vanessa Rocha Ribeiro, José Carlos Peraçoli, Leandro Gustavo de Oliveira, Camila F. Bannwart-Castro |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), New York Presbyterian Hosp, Weill Cornell Med Coll |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Placental growth factor Embryology Physiology Placenta Maternal Health lcsh:Medicine Blood Pressure Pathology and Laboratory Medicine Biochemistry Vascular Medicine Placental Growth Factor chemistry.chemical_compound Endocrinology 0302 clinical medicine Pre-Eclampsia Pregnancy Immune Physiology Medicine and Health Sciences Medicine Age of Onset lcsh:Science Innate Immune System 030219 obstetrics & reproductive medicine Multidisciplinary Obstetrics and Gynecology Interleukin-10 Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure Infarction Hypertension embryonic structures Cytokines Female Tumor necrosis factor alpha Anatomy Research Article Adult medicine.medical_specialty Immunology Preeclampsia Andrology 03 medical and health sciences Signs and Symptoms Hypertensive Disorders in Pregnancy Diagnostic Medicine Growth Factors Humans Placenta Growth Factor Fibrin Vascular Endothelial Growth Factor Receptor-1 Endocrine Physiology Tumor Necrosis Factor-alpha business.industry lcsh:R Reproductive System Granulocyte-Macrophage Colony-Stimulating Factor Biology and Life Sciences Proteins Molecular Development Endoglin medicine.disease Pregnancy Complications 030104 developmental biology chemistry Immune System Women's Health Histopathology lcsh:Q business Developmental Biology |
| Zdroj: | PLoS ONE, Vol 11, Iss 6, p e0157584 (2016) PLoS ONE Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1932-6203 |
| Popis: | Made available in DSpace on 2018-11-26T16:40:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-06-17 Preeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia (PE). We evaluated 20 normotensive pregnant women, 40 with early-onset PE and 80 with late-onset PE. Placental samples were analyzed for histopathology, immunohistochemistry and determination of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), placental growth factor (PlGF), vascular endothelial growth factor (VEGF), fms-like tyrosine-kinase-1 (Flt-1) and endoglin (Eng) levels. Higher percentages of increased syncytial knots and increased perivillous fibrin deposits, and greater levels of TNF-alpha, TGF-beta 1 and Flt-1 were detected in placentas from early-onset PE. Levels of IL-10, VEGF and PlGF were decreased in PE versus normotensive placentas. Both the TNF-alpha/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset PE than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE. Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, BR-18618970 Botucatu, SP, Brazil New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY USA Sao Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, Brazil Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, BR-18618970 Botucatu, SP, Brazil Sao Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, Brazil |
| Databáze: | OpenAIRE |
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