Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii

Autor:	Luc Van Puyvelde, Simon G. Mathenge, Miroslav Cik, Francis P. Mudida, Josée E. Leysen, Wouters Walter Boudewijn Leopo, Jacky Van Dun, Ilse Van der Lindin, Anne Simone Josephine Lesage, Giovanni Appendino, Norbert De Kimpe, Weidong He
Rok vydání:	2002
Předmět:	Models Molecular Cell Survival Stereochemistry Clinical Biochemistry Pharmaceutical Science Chick Embryo Pharmacognosy Biochemistry chemistry.chemical_compound Neurotrophic factors Ganglia Spinal Drug Discovery Tumor Cells Cultured Animals Humans Nerve Growth Factors Orthoester Molecular Biology Neurons Leukemia Molecular Structure biology Terpenes Organic Chemistry In vitro toxicology Biological activity biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Terpenoid chemistry Thymelaeaceae Molecular Medicine Diterpenes Diterpene
Zdroj:	Bioorganic & Medicinal Chemistry. 10:3245-3255
ISSN:	0968-0896
Popis:	Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa7db602da998f88d0a94f8fe21ac49 https://doi.org/10.1016/s0968-0896(02)00163-3 Zobrazit plný text záznamu Full Text from ScienceDirect