Bombesin-induced HPA and sympathetic activation requires CRH receptors
| Autor: | Zul Merali, Pamela Kent, Hymie Anisman, Samir Khan, Tania Bédard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Physiology Pituitary-Adrenal System Receptors Corticotropin-Releasing Hormone Biochemistry Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Norepinephrine Endocrinology Corticosterone Gastrin-releasing peptide Internal medicine medicine Animals Receptor Bombesin Rats Epinephrine medicine.anatomical_structure chemistry hormones hormone substitutes and hormone antagonists Signal Transduction medicine.drug Hormone |
| Zdroj: | Peptides. 22:57-65 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(00)00355-7 |
| Popis: | Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons. |
| Databáze: | OpenAIRE |
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