The clinical relevance of plasma viscosity in Hodgkin's disease
| Autor: | C.A. Angel, I. Lauder, N. Akhtar, J. Thompson, S. T. S. Durrant, J.K. Wood |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Multivariate analysis Disease Leukocyte Count Viscosity Internal medicine medicine Humans Clinical significance Plasma viscosity Aged Retrospective Studies Hodgkin s medicine.diagnostic_test Proportional hazards model business.industry Remission Induction Hematology Middle Aged Blood Viscosity Prognosis Combined Modality Therapy Hodgkin Disease Erythrocyte sedimentation rate Immunology Female business |
| Zdroj: | Clinical & Laboratory Haematology. 13:1-8 |
| ISSN: | 0141-9854 |
| DOI: | 10.1111/j.1365-2257.1991.tb00245.x |
| Popis: | Summary The erythrocyte sedimentation rate has previously been identified as an important prognostic factor in Hodgkin's disease. The plasma viscosity has replaced the ESR measurement in many laboratories, but doubts exist about its clinical relevance. In this study plasma viscosity at presentation/diagnosis was studied in 107 patients with Hodgkin's disease. A multivariate analysis of factors influencing prognosis and relapse-free survival identified plasma viscosity and number of disease sites as being highly significant. The risk of relapse increases initially with a rise in plasma viscosity, but after a value of about 2.0 mPa.s no further increase in risk is observed. When all of the prognostic factors are made available to the proportional hazards model, treatment modality and plasma viscosity are selected as the best set for predicting time to first relapse. This study demonstrates that measurement of plasma viscosity at presentation is an important prognostic factor in Hodgkin's disease, in terms of predicting outcome or risk of relapse. |
| Databáze: | OpenAIRE |
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