The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery
| Autor: | Sithembile Sibanda, JM Lynne Hughes, Christopher R. Bellenger, Patricia E Pawson, Gabrielle E. Kelly |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Injections Epidural Knee Injuries Anesthesia Spinal Cruciate ligament Dogs White blood cell Preoperative Care medicine Animals Clinical significance Prospective Studies Anesthetics Local Anterior Cruciate Ligament Pain Measurement Bupivacaine Pain Postoperative Morphine General Veterinary business.industry Anterior Cruciate Ligament Injuries Acute-phase protein Repeated measures design Stifle Surgery Analgesics Opioid Treatment Outcome medicine.anatomical_structure Anesthesia Drug Therapy Combination Female Analysis of variance business medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 33:246-257 |
| ISSN: | 1467-2987 |
| DOI: | 10.1111/j.1467-2995.2005.00261.x |
| Popis: | To evaluate the efficacy of preoperative extradural bupivacaine and morphine in attenuating the stress response in dogs undergoing femoro-tibial joint surgery.Prospective clinical study. Animal population Twelve client-owned dogs undergoing surgery for either repair of cruciate ligament rupture (ten) or correction of luxating patella (two). Body masses ranged from 12 to 45 kg (mean: 28.58 +/- 18.38). Age ranged from 19 to 121 months (mean: 66.5 +/- 49.5).Six of the dogs received extradural bupivacaine (up to 1.5 mg kg(-1)) combined with morphine (0.1 mg kg(-1); ED) while the other six received no extradural analgesia (C). The levels of cortisol, acute phase proteins (APPs), and red and white blood cell variables were measured in both groups of dogs before, and at various times after surgery. Pain was also assessed at various times after surgery. The number of postoperative morphine doses required, and their time of administration, was recorded for each animal. Method of statistical analysis Data were analysed using anova for repeated measures with p-values of0.05 considered significant.Cortisol levels in the ED group were significantly (p0.05) lower than those of the control group at the end of surgery. No statistically significant differences were found in APPs or red and white cell variables between dogs receiving, and those not receiving extradural bupivacaine and morphine. Four dogs in the control group and one in the ED group required postoperative morphine.Pre-emptive extradural bupivacaine and morphine was effective in lowering the neuroendocrine stress response (cortisol) in the ED group but had no effect on the inflammatory response (acute phase response). |
| Databáze: | OpenAIRE |
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