Alteration of SMRT Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas
| Autor: | Pushpankur Ghoshal, Qing Zhang, Elizabeth Nacheva, Lucio Miele, Qun Jiang, Sylvie Galiègue-Zouitina, Richard I. Fisher, Christiane Houde, Sanne Weijzen, Daniel Catovsky, Eric Davis, Lynda Li Song, Danny Yagan, Andrei Zlobin, Lionel J. Coignet, Thomas M. Grogan |
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| Rok vydání: | 2005 |
| Předmět: |
Transcriptional Activation
Cancer Research Tumor suppressor gene Retinoic acid Down-Regulation Apoptosis Biology law.invention chemistry.chemical_compound immune system diseases law Cell Line Tumor hemic and lymphatic diseases medicine Humans Gene silencing Genes Tumor Suppressor Nuclear Receptor Co-Repressor 2 Oligonucleotide Array Sequence Analysis Gene Rearrangement Chromosomes Human Pair 12 Thyroid hormone receptor Lymphoma Non-Hodgkin Nuclear Proteins Gene rearrangement medicine.disease Phenotype Molecular biology Lymphoma DNA-Binding Proteins Repressor Proteins Cell Transformation Neoplastic Oncology chemistry Immunoglobulin J Recombination Signal Sequence-Binding Protein Suppressor Gene Deletion |
| Zdroj: | Cancer Research. 65:4554-4561 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-04-4108 |
| Popis: | Indolent non-Hodgkin lymphomas are characterized by a prolonged phase that is typically followed by a clinical progression associated with an accelerated clinical course and short survival time. Previous studies have not identified a consistent cytogenetic or molecular abnormality associated with transformation. The development of a transformed phenotype, evolving from the original low-grade component, most likely depends on multiple genetic events, including the activation of synergistic dominant oncogenes and a loss of tumor suppressor gene functions. Complex karyotypes and relatively bad chromosome morphology are typical of transformed non-Hodgkin lymphomas, rendering complete cytogenetic analysis difficult. Here, we report the use of transformed non-Hodgkin lymphoma cell lines and primary samples to identify the involvement of the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) gene that maps at chromosome 12q24 in transformed non-Hodgkin lymphomas. We also show that down-regulation of SMRT in the immortalized “Weinberg's model” cell lines induces transformation of the cells. Assessment of cDNA array profiles should further help us to design a working model for SMRT involvement in non-Hodgkin lymphoma transformation as a novel, nonclassical tumor suppressor. |
| Databáze: | OpenAIRE |
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