Exercise at lunchtime: effect on glycemic control and oxidative stress in middle-aged men with type 2 diabetes

Autor: Paola Sbriccoli, Laura Guidetti, Luigi Di Luigi, Raffaella Buzzetti, Jonida Haxhi, Daniela Caporossi, Cristina Fantini, Gaetano Leto, Alessandro Scotto di Palumbo, Massimo Sacchetti
Rok vydání: 2015
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Sports medicine
Physiology
Urinary system
030209 endocrinology & metabolism
Walking
Type 2 diabetes
medicine.disease_cause
Postprandial hyperglycemia
03 medical and health sciences
Brisk walking
Continuous glucose monitoring
Exercise timing
Urinary isoprostanes
Aged
Diabetes Mellitus
Type 2
Humans
Lunch
Middle Aged
Postprandial Period
Exercise Therapy
Oxidative Stress
Orthopedics and Sports Medicine
Public Health
Environmental and Occupational Health
Physiology (medical)
0302 clinical medicine
Internal medicine
Diabetes Mellitus
Medicine
Glycemic
Morning
Meal
business.industry
Environmental and Occupational Health
030229 sport sciences
General Medicine
medicine.disease
Postprandial
Physical therapy
Public Health
business
human activities
Type 2
Oxidative stress
Zdroj: European Journal of Applied Physiology. 116:573-582
ISSN: 1439-6327
1439-6319
Popis: Postprandial hyperglycemia and glycemic oscillations have been associated with increased oxidative stress. We sought to investigate the effect of two walking exercise protocols performed during lunchtime on glycemic control and oxidative stress in type 2 diabetic (T2D) patients. Nine T2D patients participated in three randomized crossover trials; a control trial (Con), with participants having a standard lunch followed by their normal daily activities and two exercise trials (ContEx and Splitex). In ContEx, subjects performed 40 min of brisk walking 40 min after lunch, whereas in SplitEx the walking exercise was divided in two 20-min isoenergetic bouts, before and 40 min after meal. 24-h glycemic control was monitored by continuous glucose monitoring. 24-h urinary levels of 8-iso PGF2ɑ were measured as a marker of oxidative stress. SplitEx resulted in less time spent in moderate hyperglycemia after lunch vs ContEx (42.4 ± 38.7 % vs 68.2 ± 32.7 %, P = 0.04). ContEx reduced hyperglycemic time after breakfast consumed the morning after the exercise session (58.3 ± 29.6 Con vs 40.2 ± 33.4 % ContEx, P = 0.02). Compared with Con, 24-h urinary isoprostanes were decreased both in ContEx (−68 %, P = 0.02) and SplitEx (−63 %, P = 0.04). Splitting an exercise session into two bouts, pre- and post-lunch, affects mainly the glycemic response to lunch, while a single-continuous isoenergetic session exerts its effect later in the 24-h period. Both exercise modalities effectively attenuate systemic oxidative stress with similar overall benefits.
Databáze: OpenAIRE
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