The transformer gene of Ceratitis capitata: a paradigm for a conserved epigenetic master regulator of sex determination in insects
| Autor: | Lino C. Polito, Marco Salvemini, Giuseppe Saccone |
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| Přispěvatelé: | Saccone, Giuseppe, Salvemini, Marco, Polito, Catello |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Epigenomics
Male Molecular Sequence Data sex determination Nerve Tissue Proteins Plant Science Biology Evolution Molecular Nasonia vitripennis splicing Transformation Genetic Genes Regulator evolution Genetics Animals Drosophila Proteins Gene silencing Amino Acid Sequence Gene Silencing Epigenetics Gene autoregulation Gene Expression Regulation Developmental Nuclear Proteins RNA-Binding Proteins General Medicine Ceratitis capitata Sex Determination Processes biology.organism_classification Human genetics DNA-Binding Proteins Divergent evolution Alternative Splicing Drosophila melanogaster Ribonucleoproteins Lucilia cuprina insect pest control Insect Science Insect Proteins Female Animal Science and Zoology Transcription Factors |
| Zdroj: | Genetica ('s-Gravenhage. Print) (2010). info:cnr-pdr/source/autori:Saccone G, Salvemini M, Polito LC./titolo:The transformer gene of Ceratitis capitata: a paradigm for a conserved epigenetic master regulator of sex determination in insects./doi:/rivista:Genetica ('s-Gravenhage. Print)/anno:2010/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| Popis: | The transformer gene in Ceratitis capitata (Cctra ep ) is the founding member of a family of related SR genes that appear to act as the master epigenetic switch in sex determination in insects. A functional protein seems to be produced only in individuals with a female XX karyotype where it is required to maintain the productive mode of expression through a positive feedback loop and to direct female development by instructing the downstream target genes accordingly. When zygotic activation of this loop is prevented, male development follows. Recently, tra ep orthologues were isolated in more distantly related dipteran species including Musca domestica, Glossina morsitans and Lucilia cuprina and in the Hymenopterans Apis mellifera and Nasonia vitripennis. All of these tra ep orthologues seem to act as binary switches that govern all aspects of sexual development. Transient silencing leads to complete masculinization of individuals with a female karyotype. Reciprocally, in some systems it has been shown that transient expression of the functional TRA product is sufficient to transactivate the endogenous gene and implement female development in individuals with a male karyotype. Hence, a mechanism based on tra ep epigenetic autoregulation seems to represent a common and presumably ancestral single principle of sex determination in Insecta. The results of these studies will not only be important for understanding divergent evolution of basic developmental processes but also for designing new strategies to improve genetic sexing in different insect species of economical or medical importance. |
| Databáze: | OpenAIRE |
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